Sincalide
Also referenced as: Kinevac, CCK octapeptide
A synthetic CCK fragment used in specialist gastrointestinal diagnostic procedures.
- Evidence grade
- BModerate Human Evidence
Moderate Human Evidence
- Regulatory status
- FDA Approved for Specific Indication
Kinevac is FDA-approved for specified adult diagnostic procedures, including gallbladder and pancreatic-function assessment and accelerating barium transit.
- Human data
- Yes
Registered clinical trials exist
- Last reviewed
- October 27, 2026
Overview
A synthetic CCK fragment used in specialist gastrointestinal diagnostic procedures.
Kinevac is FDA-approved for specified adult diagnostic procedures, including gallbladder and pancreatic-function assessment and accelerating barium transit.
A diagnostic response is not evidence of an ongoing treatment benefit for gallbladder disease.
Why It's Being Studied
- Gallbladder assessment
- Pancreatic diagnostic testing
Mechanism of Action
It stimulates gallbladder contraction and pancreatic secretion, allowing selected physiological functions to be measured.
It stimulates gallbladder contraction and pancreatic secretion, allowing selected physiological functions to be measured. A diagnostic response is not evidence of an ongoing treatment benefit for gallbladder disease.
From molecular target to clinical evidence
Tap each stage to see what happens.
Background: Clinical Peptide Medicines
Clinical peptide medicines include endocrine treatments, antimicrobial drugs, receptor blockers and targeted diagnostic or cancer agents. They do not share one mechanism or one set of indications.
An approval belongs to a specific medicine and indication. A diagnostic tracer, an antibiotic and a hormone are not interchangeable wellness products; read each profile's own mechanism and prescribing source.
Research Areas & Routes Studied
- Gallbladder assessment
- Pancreatic diagnostic testing
- Intravenous diagnostic medicine
Evidence Summary
Human physiological evidence supports specific diagnostic procedures rather than treatment of chronic digestive symptoms.
Higher tiers carry more weight. Filled tiers have evidence for Sincalide; tap to read it.
- Human physiological evidence supports specific diagnostic procedures rather than treatment of chronic digestive symptoms.
1 cited sources.
- Prescribing label1
Human clinical evidence
- Human physiological evidence supports specific diagnostic procedures rather than treatment of chronic digestive symptoms.
Reported Adverse Events in Research
- Hypersensitivity or anaphylaxis, abdominal symptoms and possible gallstone displacement are important risks.
Limitations of Current Evidence
- A diagnostic response is not evidence of an ongoing treatment benefit for gallbladder disease.
- Findings apply to the product, route and population studied; they do not establish benefits or safety for unrelated wellness uses or research-vial products.
How to Read This Research
- Is this a single molecule or a family of medicines?
- Is the use diagnostic, therapeutic or investigational?
- Does the quoted outcome match the exact product, formulation and population?
- Use the compound-specific mechanism above; this diagram describes drug development, not a shared biological pathway.
- Historical approval, present availability and off-label use are distinct questions.
- For radiopharmaceuticals and hospital medicines, specialist handling is part of the treatment context.
- Indication
- The condition and population for which a medicine is approved.
- Antagonist
- A compound that blocks activity at a receptor.
- Radiopharmaceutical
- A medicine containing a radioactive isotope for imaging or treatment.
Compare With Other Compounds
| Sincalide | Trofinetide | |
|---|---|---|
| Evidence grade | B — Moderate Human Evidence | B — Moderate Human Evidence |
| Regulatory status | FDA Approved for Specific Indication | FDA Approved for Specific Indication |
| Human data | Yes | Yes |
| Clinical trials | Registered trials exist | Registered trials exist |
| Research routes | Intravenous diagnostic medicine | Oral approved medicine |
| Cited sources | 1 | 2 |
Frequently Asked Questions
Research References
- Prescribing label
Sincalide — prescribing label