Understanding Our Evidence Grades
Every compound in the library carries a grade from A to E. Here is exactly what each grade means and how it is assigned.
An evidence grade answers one question: how much do we actually know about this compound in humans? It is not a rating of promise, popularity or mechanism elegance.
The scale
Grade A means multiple randomised controlled trials in humans, typically supporting an approved indication. Grade B means several human trials exist but are limited in size, duration or consistency. Grade C means early-phase or single-centre human research only.
Grade D means animal and laboratory research with no meaningful human data. Grade E means very little published research of any kind, where discussion is largely theoretical or anecdotal.
What a grade does not tell you
A grade is not a safety score. A grade D compound is not safe by default because nothing has been reported; nothing has been measured.
A grade is also not a regulatory status. Approval and evidence are related but distinct, which is why every compound page displays both.
This article is educational and is not medical advice. It does not recommend or provide individualised dosing. Speak with a qualified healthcare professional about your own health.