5-Amino-1MQ
Also referenced as: 5-amino-1-methylquinolinium, NNMT inhibitor
A small-molecule NNMT inhibitor discussed alongside peptides, with no human evidence base.
- Evidence grade
- DPreclinical Research
Preclinical Research
- Regulatory status
- Research Use Only
- Human data
- No
No registered clinical trials identified
- Last reviewed
- September 1, 2026
Overview
Despite being grouped with peptides in consumer discussion, 5-Amino-1MQ is a small molecule, not a peptide. It inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ salvage and adipocyte metabolism.
All meaningful data are preclinical. Marketing language about metabolic transformation is not supported by human research.
Why It's Being Studied
- NNMT's role in adipose tissue metabolism and NAD+ availability.
- Whether NNMT inhibition alters fat mass in metabolic disease models.
Mechanism of Action
It blocks an enzyme that consumes a molecule cells use for energy metabolism, which in animals shifted how fat cells behaved.
NNMT methylates nicotinamide, diverting it from NAD+ salvage. Inhibition raises intracellular nicotinamide and NAD+ in adipocytes and has been associated in rodent models with reduced adipose tissue mass and altered lipogenic gene expression.
Research Areas & Routes Studied
- Adipose metabolism
- NAD+ biology
- Oral (in animal research)
Evidence Summary
Rodent and cell studies only. No published human clinical trials were identified at last review.
Animal studies
- Diet-induced obesity models reported reduced fat mass with NNMT inhibition.
In-vitro studies
- Adipocyte studies characterised NNMT inhibition and NAD+ changes.
Anecdotal / community information
- Community claims about weight loss and muscle preservation have no human trial support. No established human dosing protocol exists.
Reported Adverse Events in Research
- No human safety data. Adverse effects in people are unknown rather than absent.
Limitations of Current Evidence
- Preclinical only; rodent adipose biology translates unreliably to humans.
- Product identity and purity in the research-use-only market are frequently undocumented.
Why It Is Used
- Metabolic Health
Visceral Fat and Metabolic Markers
Not weight on a scale, but the fat around the organs — the compartment most strongly tied to metabolic risk.
Read the case study
Research References
- Animal study
Small molecule NNMT inhibition and adipose tissue metabolism