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Protocol Reference
GHK-Cu (copper tripeptide-1)

GHK-Cu — topical study protocols as reported

Summarise how topical GHK-Cu has been applied in published cosmetic and wound-healing studies.

Not FDA ApprovedReviewed September 1, 2026
No established human dosing protocol exists for this compound. What follows describes the research context only — the conditions under which the compound has been studied, usually in animals or in vitro.

Research Context

Source of this information
Almost all defensible protocol information for GHK-Cu concerns topical application in cosmetic formulations.
Evidence level
Grade C — small controlled cosmetic studies plus extensive in-vitro work
Population studied
Adults with photoaged skin in small cosmetic studies; animal models for wound healing.
Duration studied
Typically 8 to 12 weeks of twice-daily application in reported cosmetic studies.
Route reported
Topical application in a formulated cream or serum

Protocol as Reported

  • 01Reported studies applied a formulated product containing a low percentage of copper tripeptide once or twice daily to the study area.
  • 02Assessments included instrumented measures of skin density and elasticity alongside investigator wrinkle scoring.
  • 03Wound-healing research in animals used topical or intradermal application at the wound site.

Adverse Events Reported

  • Local irritation and contact sensitivity are possible with topical use.
  • No established safety profile exists for injected or systemic administration.

Limitations

  • Human studies are small and often industry-sponsored, with cosmetic rather than clinical endpoints.
  • Topical evidence must not be transferred to injection, for which no protocol exists.

Sources

  • Randomised controlled trial

    Topical copper tripeptide in photoaged skin: controlled study

    View Study
  • Narrative review

    GHK peptide and skin regeneration pathways

    View Study
Read the full GHK-Cu research guide
Educational reference only. Peptide Atlas does not provide medical advice or individualised dosing guidance, and nothing on this page should be used to guide personal use.